Tuesday, 2 September 2014

Nigeria to Test Ebola Trial Drug, TKM-Ebola on 3 Patients

The Health Minister,  Onyebuchi Chukwu says Nigeria has ordered for the Ebola experimental drug from Japan to be tested on three Ebola patients in Nigeria. He added that 278 contacts under surveillance in Lagos have been released after completing their 21 days observation and showed no trace of the disease. According to Chukwu, the Treatment Research Group (TRG) which he had informed earlier, had been working hard to identify experimental drugs like Zmapp, and also make recommendations to government on further research on these drugs as well as vaccines for Ebola Virus Disease (EVD) treatment and prevention.

"Following the TRG’s recommendation and in consultation with NAFDAC and NHREC, Nigeria has indicated interest to participate in the clinical trials for two candidate EVD vaccines and are considering a third that may be added to the list. We have also applied for experimental drugs such as TKM-Ebola.

"The TRG has submitted a detailed profile and brief on the oral antiviral agent which the Japanese government has offered to make available to affected countries through the WHO. We are now considering this profile and brief to enable us reach a final decision on making it available to our patients.

"Our initial knowledge of the agent is that it has been shown to have strong antiviral activity against the influenza virus following phases I and II human trials, it is now going through phase III clinical trials; it is shown to have strong antiviral property against Ebola Virus in vitro and in vivo. These and the fact that it is considered safe, having passed through phases I and II clinical trials, makes it a good candidate drug for use in emergency situations as the EVD," he explained.

Chukwu said government was taking a holistic approach to the containment of EVD in Nigeria.

He added that as at 31st August, 2014, the number of contacts under surveillance in Lagos stood at 72 while in Port Harcourt, the total number of contacts under surveillance stood at 199.

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